Scientists recently deciphered the structure of the protein methyltransferase from the monkeypox virus. It is with the help of methyltransferase protein that the virus escapes human immunity and causes monkeypox disease.
Dimensions of the Article:
- About Monkeypox virus
- Zoonotic disease
- Symptoms and treatment
About Monkeypox virus
- The monkeypox virus is an orthopoxvirus, which is a genus of viruses that also includes the variola virus, which causes smallpox, and vaccinia virus, which was used in the smallpox vaccine.
- Monkeypox causes symptoms similar to smallpox, although they are less severe.
- While vaccination eradicated smallpox worldwide in 1980, monkeypox continues to occur in a swathe of countries in Central and West Africa, and has on occasion showed up elsewhere.
- According to the World Health Organisation (WHO), two distinct clade are identified: the West African clade and the Congo Basin clade, also known as the Central African clade.
- Monkeypox is a zoonosis, that is, a disease that is transmitted from infected animals to humans.
- According to the WHO, cases occur close to tropical rainforests inhabited by animals that carry the virus.
- Monkeypox virus infection has been detected in squirrels, Gambian poached rats, dormice, and some species of monkeys.
- Human-to-human transmission is, however, limited — the longest documented chain of transmission is six generations, meaning the last person to be infected in this chain was six links away from the original sick person, the WHO says.
- Transmission, when it occurs, can be through contact with bodily fluids, lesions on the skin or on internal mucosal surfaces, such as in the mouth or throat, respiratory droplets and contaminated objects.
Symptoms and treatment
- According to the US Centers for Disease Control and Prevention (CDC), monkeypox begins with a fever, headache, muscle aches, back ache, and exhaustion.
- It also causes the lymph nodes to swell (lymphadenopathy), which smallpox does not.
- The WHO underlines that it is important to not confuse monkeypox with chickenpox, measles, bacterial skin infections, scabies, syphilis and medication-associated allergies.
- The incubation period (time from infection to symptoms) for monkeypox is usually 7-14 days but can range from 5-21 days.
- Usually within a day to 3 days of the onset of fever, the patient develops a rash that begins on the face and spreads to other parts of the body.
- The skin eruption stage can last between 2 and 4 weeks, during which the lesions harden and become painful, fill up first with a clear fluid and then pus, and then develop scabs or crusts.
- According to the WHO, the proportion of patients who die has varied between 0 and 11% in documented cases, and has been higher among young children.
- There is no safe, proven treatment for monkeypox yet.
- The WHO recommends supportive treatment depending on the symptoms.
- Awareness is important for prevention and control of the infection.
-Source: Indian Express