Context:
Researchers from the Korean Institute of Basic Science have developed a magnetogenetics technology dubbed Nano Magnetogenetic Interface for NeuroDynamics (Nano-MIND) which has been demonstrated on mice.
Relevance:
GS III: Science and Technology
Nano-MIND Technology: Overview and Highlights
Overview
- Nano-MIND (Magnetogenetic Interface for NeuroDynamics): This cutting-edge technology offers new avenues for exploring and influencing complex brain functions, including cognition, emotion, and motivation.
- Functionality: It enables wireless, remote, and precise modulation of specific deep brain neural circuits using magnetic fields and magnetized nanoparticles. This method represents a significant improvement over traditional brain manipulation techniques.
Research Highlights
- Demonstration on Mice: The research team showcased Nano-MIND’s capabilities by activating particular neurons in various brain regions of mice.
- Maternal Behavior Induction: One key achievement was the activation of inhibitory GABA receptors in the medial preoptic area (MPOA), known for governing maternal behaviors. When these neurons were stimulated in non-maternal female mice, the animals displayed markedly increased nurturing behaviors similar to those of maternal mice.
- Regulation of Feeding Behaviors: The researchers also targeted motivation circuits in the lateral hypothalamus to regulate feeding behaviors. Activating inhibitory neurons in this region led to a significant 100% increase in appetite and feeding behaviors in mice. In contrast, activating excitatory neurons resulted in more than a 50% reduction in these behaviors.
Significance
- Advancement in Neuroscience: Nano-MIND technology marks a major advancement in neuroscience, potentially revolutionizing our understanding of brain functions and disorders.
- Applications: The technology holds promise for developing advanced brain-computer interfaces (BCIs) and could play a critical role in treating neurological disorders, offering new avenues for therapeutic interventions.
-Source: India Today
