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Coating developed by JNCASR may prevent transmission of infection:


Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) has developed a one-step curable anti-microbial coating which, when coated on different surfaces such as textile, plastic and so on could kill a range of virus types including COVID 19.

Coating developed by JNCASR may prevent transmission of infection

Details:

  • The recent outbreak of SARS-CoV-2 has created an unprecedented stir in global public health. Like influenza, Coronavirus is also an enveloped virus
  • JNCASR has developed a one-step curable anti-microbial coating which, when coated on different surfaces such as textile, plastic and so on could kill a range of virus types including COVID 19.
  • This covalent coating  has been found to completely kill influenza virus as well as resistant pathogenic bacteria and fungi, including methicillin-resistant Staphylococcus aureus and fluconazole-resistant C. albicans spp.
  • In brief, for coating on cotton, the sheets were dipped in a water solution of the compounds whereas, for other cases, ethanolic substrates were drop-casted on them followed by UV irradiation. (In chemistry, a substrate can refer to a surface on which other chemical reactions are performed)
  • After coating, the surfaces were evaluated for their antibacterial, antifungal, and antiviral activity.
  • Upon the formation of the coating, it has been shown to permeabilize the membranes of pathogens (i.e. bacteria) leading to their inactivation.

Benefits:

  • Can help prevent contamination: 
    • Till date(to the best of our knowledge) there is no covalent coating strategy which can kill all viruses, bacteria and fungi. 
    • Therefore it is anticipated that the coating may inactivate SARS-CoV-2 upon contact and can help prevent contamination if coated on various surfaces.
  • The coating can be fabricated on a variety of surfaces, and its ease and robustness eliminate the necessity of skilled personnel for procurement of the coating.
  • Ability to cross-link: The molecules developed have an ability to chemically cross-link with different surfaces upon UV irradiation. 

Considering the current coronavirus outbreak, if shown to be active, the molecule can be synthesized in large scale through a CRO (Contract Research Organization) and can be coated on various personal protective tools such as masks, gloves, gowns, etc. in collaboration with the private organizations. 

Extra notes:

Enveloped Virus

  • A virus that has an outer wrapping or envelope. This envelope comes from the infected cell, or host, in a process called “budding off.” 
  • During the budding process, newly formed virus particles become “enveloped” or wrapped in an outer coat that is made from a small piece of the cell’s plasma membrane. 
  • The envelope may play a role in helping a virus survive and infect other cells.
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December 2022
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