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  • Leucine-rich repeat kinase 2 (LRRK2) is a kinase enzyme that protects the body against viral and bacterial infections by triggering inflammation like swelling, redness, heat and pain.
  • According to a recent study, this enhanced inflammation can lead to collateral damage to the body.
  • Inflammation caused by mutation in a gene can raise the risk of Parkinson’s and Crohn’s diseases as well as leprosy.
  • Leprosy caused by infections characterised by lesions in the nerve endings of the skin.
  • LRRK2, which causes excessive inflammation to defend body against a type of mycobacterium infects peripheral nerves, is thought to be behind leprosy.
  • The findings are also important for ongoing clinical trials of Parkinson’s drugs that can reduce excessive LRRK2 activity.
  • However, total absence of LRRK2 function can make people more prone to infections.

LRRK2 was recently on science news portals, it is a

  1. Gene
  2. Hormone
  3. Kinase enzyme
  4. Asteroid
December 2023