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Stem Cell-derived Mitochondria Transplantation

Context:

Recently, six children with rare disorders caused by deletion in the genomes of their mitochondria were successfully treated for the first time by Stem-cell derived Mitochondria Transplantation.

Relevance:

Facts for Prelims

What is the Stem Cell-derived Mitochondria Transplantation?

  • The process involved the mitochondrial transplant from donor mothers into children’s haematopoietic stem cells, which give rise to all types of blood cells.
  • It involves the spontaneous mitochondrial transfer of the stem cell to rescue the injured cells or the injection of stem cell isolated mitochondria into the injured area to repair the damage.
  • Stem cells are the most primitive cells at the top of the origin of cell lines, and they have a high capacity for differentiation and self-renewal.
  • In addition, stem cells can differentiate into various tissues, organs, or functional cells of the human body; therefore, stem cells hold great promise for therapeutic tissue engineering and regenerative medicine.

-Source: The Hindu


February 2023
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